A healthy Lifestyle decreases inflammation, therefore anti inflammation equals wellness. Chronic “silent” inflammation is the cause and the effect of most illnesses and the diseases of aging. It set up a vicious cycle, and causes the degenerative diseases and those will trigger more inflammation. Chronic inflammation slowly kills us

We will firstly consider the patient’s lifestyle, including nutrition, nutraceutical, detoxification, stress reduction and exercise. The marker of inflammation such as CRP, homocysteine, IL6, TNF alpha, IL-1 beta, insulin level, AA/EPA ratio should be determined.

Supplementary omega 3 FA ;EPA inhibits NF kB and decreases TNF , CRP (acute phase protein) and other proinflammtory cytokines. Omega 3 is essential for favorable eicosanoid hormone production. Taking vit B6,B 12 and folic acid is important to avoid hyperhomocysteinemia.

Craving for starches may denote a deficiency for the neurotransmitter serotonin. The precursor is 5 hydroxytryptophan, by giving these neurotransmitter precursors before the cravings occur, may delay hunger.

Resveratrol activate a family of genes called sirtuins (SIRT-1) ahich are known as the longevity genes, these gens protect and repair cells and cellular survival

Chung et al found that calorie restriction (800kcal /day) decreases levels of inflammatory cytokines. Nuclear Factor kappa beta, a transcription factor, may be the centerpiece of the whole inflammatory cascade. The inflammatory cytokines activate NFκβ ; Pro oxidants such as free radicals activate NF kappa beta, turns to inflammatory enzymes COX 2, 5 LOX and Phosopholipase A2 , the adhesion molecules VCAM-1 and ICAM-! , these adhesion molecules play important roles in lots of disease processes.

One of the best ways of fighting chronic inflammation is to alter the diet. Mediterranean diet originated from Italy and southern France consist of large amount of vegetables, legumes, fruits, nuts , whole grain, cereal, fish.Incorporating vegetables into at least 30% of the daily diet will provide high levels of dietary antioxidants and support the detoxification mechanisms of the liver by stimulating Phase and phase 2 detoxification mechanismus Several studies suggest that the is due to its CRP lowering effect CRP is more than a marker, it is prothrombotic, a pro inflammatory substance

Psychoneuroimmunology suggests that proinflammtory cytokine production can be directly stimulated by negative emotions and stressful experiences.

Adequate sleep decreases iinflammation , possible because GH is made in stage III and IV sleep. Exercise at the other hand are good , fitness levels are inversely associated with CRP levels.